The term lupus pernio is a misnomer because the condition is not associated with lupus and has no association with pernio.
Lupus pernio is a rare but characteristic skin manifestation of sarcoidosis. The lesions are often deforming and appear as chronic, hyperpigmented or violaceous nodules or plaques of the nose, cheeks, ears, and central face. Histology shows sarcoidal granulomas .
Pernio, or chilblains, is a localized inflammatory lesion of the skin resulting from an abnormal response to cold. Pernio most commonly occurs in young women but may occur in older individuals or in children. Single or multiple erythematous-to-purplish, edematous plaques appear secondary to cold exposure and are accompanied by intense pain, itching, or burning .
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